Kurt Cobain: Nine Memorable Quotes from the Nirvana Frontman
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Or, Lies, Damned Lies and Quote Mines
Liver cirrhosis is associated with decreased HRV. Decreased HRV in patients with cirrhosis has a prognostic value and predicts mortality. Loss of HRV is also associated with higher plasma pro-inflammatory cytokine levels and impaired neurocognitive function in this patient population.
HRV is decreased in patients with sepsis. Loss of HRV has both diagnostic and prognostic value in neonates with sepsis. Patients with chronic complete high cervical spinal cord lesions have intact efferent vagal neural pathways directed to the sinus node. However, an LF component can be detected in HRV and arterial pressure variabilities of some tetraplegic patients. Thus, the LF component of HRV in those without intact sympathetic inputs to the heart represent vagal modulation.
Patients victim of sudden cardiac death have been found to have lower HRV than healthy individuals. HRV correlates with the progression of disease and outcome of cancer patients, according to a systematic review of published studies.
Interventions that augment HRV may be protective against cardiac mortality and sudden cardiac death. Although the rationale for changing HRV is sound, it also contains the inherent danger of leading to the unwarranted assumption that modification of HRV translates directly into cardiac protection, which may not be the case. Despite the growing consensus that increases in vagal activity can be beneficial, it is not as yet known how much vagal activity or HRV as a marker has to increase in order to provide adequate protection.
Despite the observation of statistically significant increases, the actual changes are very modest. Data exist for several antiarrhythmic drugs. Flecainide and propafenone but not amiodarone were reported to decrease time domain measures of HRV in patients with chronic ventricular arrhythmia. A larger study confirmed that flecainide, also encainide and moricizine, decreased HRV in post-MI patients but found no correlation between the change in HRV and mortality during follow-up.
Thus, some antiarrhythmic drugs associated with increased mortality can reduce HRV. However, it is not known whether these changes in HRV have any direct prognostic significance. Low-dose muscarinic receptor blockers, such as atropine and scopolamine, may produce a paradoxical increase in vagal effects on the heart, as suggested by a decrease in heart rate. In addition, scopolamine and low dose atropine can markedly increase HRV. However, though the heart rate slowing in proportional to the low dose of atropine, the increase in HRV varies widely across and within individuals.
This suggests that even for vagal activity to the heart, HRV may be a limited marker. HRV was higher 90 minutes after thrombolysis in the patients with patency of the infarct-related artery. However, this difference was no longer evident when the entire 24 hours were analyzed. Exercise training may decrease cardiovascular mortality and sudden cardiac death.
Regular exercise training is also thought to modify cardiac autonomic control. Individuals who exercise regularly have a 'training bradycardia' i. The technique called resonant breathing biofeedback teaches how to recognize and control involuntary heart rate variability. A randomized study by Sutarto et al.
One study that surveyed the physiological effects of playing Native American flutes found a significant HRV increase when playing both low-pitched and high-pitched flutes. From Wikipedia, the free encyclopedia. The American Journal of Cardiology. Journal of Cardiovascular Electrophysiology. International Journal of Psychophysiology.
Journal of Applied Physiology. Journal of the Autonomic Nervous System. Annals of the New York Academy of Sciences. Standards of measurement, physiological interpretation, and clinical use". Innys, Manby and Woodward. Accessed via Version cached by Google on on Computers in Biology and Medicine. Integrative Physiological and Behavioral Science.
Statistical Mechanics and its Applications. American Journal of Physiology. Heart and Circulatory Physiology. Journal of Statistical Mechanics: Progress in Biophysics and Molecular Biology.
Gastrointestinal and Liver Physiology. It covers all the essential things with impressive clarity, but without going into information overload, it's got a great resources section, and it manages to balance positivity with sensible realism. Marketing Yourself formerly Developing a Marketing Strategy covers various strategies for promoting an editorial business, including the importance of a professional business image.
It stresses that editors need to be looking ahead all the time and seeking new avenues of work on a regular basis — not just waiting until there is no work to do. There is advice on ways to market yourself — whether you're just starting out or have some experience and are looking to gain new clients. The guide points you in the right direction, and it will inspire and encourage you to get out there and promote yourself and your editorial business. Freelance editorial work is a professional service and no two projects are the same.
Pricing up a project involves four main elements:. Pricing a Project describes the quotation process, from taking a brief to agreeing terms and conditions. This practical guide comprises tips, checklists and worked examples to assist not only freelances but also clients who seek the services of editorial professionals. It was so packed full of information and advice that it gave me the confidence I needed when handling those first few quotes. Proofreading Theses and Dissertations introduces some of the basic principles of proofreading academic texts.
In many respects, the work required is the same as for any other proofread — you check for errors in spelling, punctuation, grammar and consistency — but it is complicated by the fact that the thesis or dissertation must be the student's own work. The guide explores the nature of this type of proofreading as well as the practicalities of how to get work, calculating fees and negotiating with students.
It then deals with potentially thorny ethical issues such as what to do with possible plagiarism and how much to query, intervene in or change the student's writing.
A badly presented document, publication or website loses credibility quickly when the reader is distracted by inconsistent spelling and usage and badly presented figures and measurements. A well-thought-out editorial house style to guide everyone who works on a document, publication or website.
This guide outlines the value of a house style and reveals how to go about constructing such guidance if one doesn't already exist. If you missed the Golden Globes , don't fear! We're breaking down all the big winners and big moments in this week's IMDbrief. Visit Prime Video to explore more titles. Find showtimes, watch trailers, browse photos, track your Watchlist and rate your favorite movies and TV shows on your phone or tablet!
Keep track of everything you watch; tell your friends. Full Cast and Crew. On Disc at Amazon. A law student uncovers a conspiracy, putting herself and others in danger.
John Grisham book , Alan J. Share this Rating Title: The Pelican Brief 6. Use the HTML below. You must be a registered user to use the IMDb rating plugin. Learn more More Like This. Courage Under Fire The Bone Collector Sleeping with the Enemy Out of Time I Edit Cast Cast overview, first billed only: Darby Shaw Denzel Washington Gray Grantham Sam Shepard Thomas Callahan John Heard Gavin Vereek Tony Goldwyn Fletcher Coal James Sikking Bob Gminski Robert Culp Justice Rosenberg John Lithgow Smith Keen Anthony Heald Marty Velmano Nicholas Woodeson Edwin Sneller John Finn Edit Did You Know?
Trivia Director Voyles' greeting to Darby Shaw, "So you're the little lady that started this great brouhaha", is likely an allusion to President Lincoln's famous apocryphal greeting to Harriet Beecher Stowe who wrote "Uncle Tom's Cabin":